한양대학교 바이오신약융합학부

학력

• 2000년 한양대학교 생명과학과 (이학사)
• 2003년 연세대학교 의과대학 (이학석사)
• 2012년 Boston University (이학박사)

 

경력

• 1) Post-doctoral researcher / UCSD / 2013~2017
• 2) Assistant Project Scientist / UCSD / 2018~2020
• 3) Staff Research Associate / UCSD / 2021~2022

 

주요연구분야

• 1) Fatty liver diseases
• 2) Metabolism
• 3) Stress Response

 

대표 연구(학술) 활동

• 1) MASH as an emerging cause of hepatocellular carcinoma: current knowledge and future perspectives. Molecular Oncology (Corresponding Author), 2024
• 2) PIDDosome-SCAP cross-talk controls fructose diet-dependent transition from simple steatosis to steatohepatitis. Cell Metabolism (First & co-corresponding Author), 2022
• 3) From Liver Fat to Cancer: Perils of the Western Diet. Cancers (First Author), 2021
• 4) ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell (First Author), 2018
• 5) The first luminal loop confers insulin responsiveness to the glucose transporter 4. Mol. Biol. Cell (First Author), 2012

 

주요 강의 과목

• 1) Molecular Biology
• 2) Molecular Biology Techniques
• 3) Hormone and Diseases

학력

• 2005: Ph.D. (TU Berlin/Max-Plank Institut fuer Infectionsbiologie)

 

경력

• Sept 2018 – Current: Hanyang University [ERICA], Korea
• Sept 2008 – June 2018: Wissenschaftlicher Mitarbeiter, CECAD, Cologne, Germany
• Sep 2005 – Jul 2008: Research Fellow, CBRC, MGH, Harvard Medical School, MA, USA
• Aug 2001 – Aug 2005, Doktorand, Max-Plank Institut fuer Infectionsbiologie, Berlin, Germany
• May 1999 – Jun 2001: Assistant Research Scientist, Samsung Biomedical Research Institute, Korea

 

주요연구분야

• 1) Signal transduction
• 2) Inflammation
• 3) Cell death

 

대표 연구(학술) 활동

• 1) RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation.
  Lin J*, Kumari S*, Kim C*, Van TM, Wachsmuth L, Polykratis A, Pasparakis M
  Nature. 2016 Dec 1; 540(7631):124-128(*Co-first authors. The order of appearance of first authors was determined by a draw.)
• 2) Epidermal p65/NF-κB signaling is essential for skin carcinogenesis.
  Kim C, Pasparakis M
  EMBO Mol Med. 2014 Jun 21; 6(7):970-83.
• 3) The kinase p38α serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression.
  Kim C, Sano Y, Todorova K, Carlson B, Arpa L, Celada A, Lawrence T, Otsu K, Brissette J, Arthur JA & Park JM
  Nat Immunol. 2008 Sep; 9(9):1019-1027
• 4) Anti-inflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus.
  Kim C, Wilcox-Adelman S, Sano Y, Tang W, Collier RJ and Park JM
  Proc Natl Acad Sci U S A. 2008 Apr 22; 105(16): 6150-6155
• 5) Human α-defensins neutralize anthrax lethal toxin and protect against its fatal consequences.
  Kim C, Gajendran N, Mittruecker H, Weiwad N, Song Y, Hurwitz R, Wilmanns M, Fisher G, Kaufmann SH
  Proc Natl Acad Sci U S A. 2005 Mar 29; 102(13): 4830-4835

 

주요 강의 과목

• 1) 암생물학
• 2) 면역학
• 3) 동물생리학

학력

• 1989, Hanyang University, BS
• 1991, Hanyang University, MS
• 1999, University of Tennessee, PhD

 

경력

• Post-doc / Harvard Medical School / 1999-2000
• Instructor / Harvard Medical School / 2000-2004
• Professor / Hanyang University / 2004-present

 

주요연구분야

My research interests are 1) to develop research tools and disease models to study neurodegenerative diseases, 2) to produce potential cell source for the cell replacement therapy to cure the diseases, 3) to understand pathophysiological mechanism of neurodegenerative diseases and 4) to discover potential therapeutic targets for next generation medicine for neurodegenerative diseases. I would like to apply my basic research findings for the translational medicine approaches for the future treatment of neurodegenerative disorders.

 

대표 연구(학술) 활동

• 1. Park Y et al. (2024) Molecular targets of histone deacetylase inhibitors in neurodegeneration and neuroprotection. Molecular & Cellular Toxicology, DOI: 10.1007/s13273-024-00441
• 2. Kim J, et al (2022) Spotting-based differentiation of functional dopaminergic progenitors from human pluripotent stem cells. Nat. Protocols 17:890
• 3. Hyeon SJ, et al (2021) Dysfunction of X-linked inhibitor of apoptosis protein (XIAP) triggers neuropathological processes via altered p53 activity in Huntington's disease. Progress in Neurobiology, https://doi.org/10.1016/j.pneurobio.2021.102110
• 4. Ryu, W-I, et al (2021) Brain cells derived from Alzheimer’s disease patients have multiple specific innate abnormalities in energy metabolism. Molecular Psychiatry, https://doi.org/10.1038/s41380-021-01068-3
• 5. Schweitzer, JS., et al. (2020) Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson’s Disease. N Engl J Med. 382: 1926-1932
• 6. Song, B., et al. (2019) Human autologous iPSC-derived dopaminergic progenitors restore motor function in Parkinson’s disease models. J. Clin. Invest. doi 10.1172/JCI130767
• 7. Kim, T., et al. (2019) HDAC inhibition by valproic acid induces neuroprotection and improvement of PD-like behaviors in LRRK2R1441G transgenic mice. Exp Neurobiol., 28: 504-515.
• 8. Cooper, O. et al. (2012) Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease. Sci Transl Med., 4;4(141):141ra90

 

주요 강의 과목

Biochemistry, Neuroscience, Virology, etc

학력

• 1996년 성균관대학교 약학과 (약학사)
• 1998년 성균관대학교 약학과 (약학석사)
• 2001년 성균관대학교 약학과 (약학박사)

 

경력

• 1) 박사후 연구원 / BCMP (Harvard Medical School) / 2001~2005
• 2) 조교수 / 의약생명과학과 (한양대학교) / 2005~2010
• 3) 국제협력 간사 / 대한약학회 / 2009 ~ 2011
• 4) 부교수 / 의약생명과학과 (한양대학교) / 2010~2015

 

주요연구분야

• 1) 후성유전 기반 항암제 개발
• 2) 후성유전 조절에 의한 유전자 발현 연구
• 3) 후성유전 조절에 의한 세포수명 조절 연구

 

대표 연구(학술) 활동

• 1) [IF: 7.8 (JCR2022), 2024 ERICA 상위4.881%] Tho2-mediated escort of Nrd1 regulates the expression of aging-related genes. Yan Liu, Jeong-Min Park, Suji Lim, Ruxin Duan, Do Yoon Lee, Dahee Choi, Dong Kyu Choi, Byung-Ho Rhie, Soo Young Cho, Hong-Yeoul Ryu, Seong Hoon Ahn, Aging Cell. 2024 Aug;23(8):e14203.
• 2) [IF: 9.207 (JCR2021), ERICA 상위4.9%] Multiple roles of CTDK‑I throughout the cell. Srivastava R, Duan R, Ahn SH. Cell Mol Life Sci. 2019 Jul;76(14):2789-2797.
• 3) [IF: 13.044 (JCR2021), ERICA 상위1.3%] The Epigenetic Pathways to Ribosomal DNA Silencing. Srivastava, R., Srivastava, R., Ahn, SH. Microbiol Mol Biol Rev. 2016 Jun 1;80(3):545-63
• 4) [IF: 17.681 (JCR2021), ERICA 상위3.8%] Modifications of RNA polymerase II CTD: Connections to the histone code and cellular function. Srivastava R, Ahn SH. Biotechnol Adv. 2015 Nov 1;33(6 Pt 1):856-72
• 5) [IF = 7.984, ERICA 상위7.3%] Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic rDNA condensation. Ryu HY, Ahn SH. BMC Biol. 2014 Sep 24;12(1):75

 

주요 강의 과목

• 1) 세포생물학
• 2) 분자세포생물학
• 3) 생명의비밀

학력

• 2004년도 충남대학교 자연과학대학 미생물학과 (이학사)
• 2006년도 충남대학교 의과대학 미생물학교실 (의학석사)
• 2008년도 충남대학교 의과대학 미생물학교실 (의학박사)

 

경력

• Research Associate / 미국 남가주대학 (USC) 의과대학 미생물학 및 면역학교실 / 2009~2012
• 조교수 / 충남대학교 의과대학 감염신호조절연구센터 / 2012~2014
• 조교수,부교수,교수 / 한양대학교 과학기술융합대학 의약생명과학과 / 2014~2024
• 교수 / 한양대학교 첨단융합대학 바이오신약융합학부 분자의약전공 / 2025~

 

주요연구분야

• 1). Microbial pathogenesis and host responses.
  (1) Molecular and cellular pathogenesis of intracellular microbes infection especially on Mycobacteria, Listeria, Candida, Toxoplasma, Influenza infection
  (2) Signal transduction mechanisms in immune and inflammatory responses
  (3) Molecular and immunopathogenesis in neuroinflammatory diseases
• 2). Host-pathogen functional interactions and its therapeutic strategies.
  (1) The role of ROS-generating NADPH oxidases activation and expression
  (2) Exploring of cell death and autophagy pathways in microbial infection
  (3) The role of nuclear receptors in innate immunity
  (4) The role of mitochondria and autophagy in innate immunity
• 3). Molecular engineering of Peptide-Drug Conjugates for therapeutics
  (1) Peptide and protein therapeutics
  (2) Pharmaceutics drug delivery and targeting

 

대표 연구(학술) 활동

• 1) Exploring the potential of Toxoplasma gondii as a drug development and delivery system. Exp Mol Med. 2024 Feb;56(2):289-300.
• 2) Inhibition of CD82 improves colitis by increasing deubiquitination activities in NLRP3 by BRCC3. Cell Mol Immunol. 2023 Feb;20(2):189-200.
• 3) Pathogen-derived peptides in Drug Targeting and its Therapeutic Approach. J Control Release. 2022 Sep 7;350:716-733.
• 4) Down-regulation of TNF-α via Macrophage-targeted RNAi system for the treatment of acute inflammatory sepsis.J Control Release. 2021 Aug 10;336:344-353.
• 5) Mycobacteria Rv2626c-derived peptide as a therapeutic agent for sepsis. EMBO Molecular Medicine 2020 Dec 7;12(12):e12497.

 

주요 강의 과목

• 1) 미생물과 인간 (교양), 전염병 클리닉 (교양)
• 2) 일반 미생물학 (2학년), 면역학 실험 (3학년), 병원 미생물학 (4학년)

 

교재 집필

• The Great Secret of Microbes - 미생물의 위대한 비밀
• The Great Secret of Microbes 2 - 미생물의 은밀한 비밀

학력

• 2000년 한양대학교 생화학과(이학사)
• 2003년 광주과학기술원 생명과학과(이학석사)
• 2008년 광주과학기술원 생명과학과(이학박사)

 

경력

• 1) 박사후 연구원 / Cardiovascular Research Center (Icahn School of Medicine at Mount Sinai, New York, USA) / 2008-2013
• 2) 전임강사 / Cardiovascular Research Center (Icahn School of Medicine at Mount Sinai, New York, USA) / 2013-2018
• 3) 조교수 / Cardiovascular Research Center (Icahn School of Medicine at Mount Sinai, New York, USA) / 2018-2020
• 4) 부교수 / 의약생명과학과 (한양대학교) / 2020-2022

 

주요연구분야

• 1) miR-25의 조절을 통한 심근증 및 심장 섬유화의 기전확립/ 치료기술 개발
• 2) CCN5 유전자의 조절을 통한 조직 섬유화의 치료 및 진단기술 개발
• 3) Cytl1 유전자의 조절을 통한 조직 섬유화 기전조절
• 4) Eya2 유전자의 발현 조절을 통한physiological hypertrophy 기전연구
• 5) 심부전 혁신 바이오마커 발굴 및 치료제 개발

 

대표 연구(학술) 활동

• 1) Inhibition of miR-25 improves cardiac contractility in the failing heart. Nature. 2014 Apr 24;508(7497):531-5
• 2) Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis. J Am Coll Cardiol. 2016 Apr 5;67(13):1556-1568.
• 3) miR-25 Tough Decoy Enhances Cardiac Function in Heart Failure. Mol Ther. 2018 Mar 7;26(3):718-729.
• 4) Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca2+-ATPase in Heart Failure. Circ Res. 2019 Apr 26;124(9):e63-e80.
• 5) Inhibition of miR-25 ameliorates cardiac and skeletal muscle dysfunction in aged mdx/utrn haploinsufficient (+/-) mice. Mol Ther Nucleic Acids. 2024 Mar 28;35(2):102174.

 

주요 강의 과목

• 1) 유전자 및 세포치료학
• 2) 중간대사론
• 3) 발생생물학
• 4) 생명과학연구론

학력

• B.S., Hanyang University, 2003
• M.S., Hanyang University, 2005
• Ph.D., Hanyang University, 2008

 

경력

• 2008.09~2009.12, Hanynag University, Postdoc
• 2010.01~2011.02, Ewha Womans University, Postdoc
• 2011.03~2012.11, Ewha Womans University, Research professor
• 2013.05~2014.12, MRC Harwell, Researcher
• 2015.02~2016.12, Seoul National University, Research professor
• 2016.12~2021.08, National Cancer Center, Senior scientist
• 2020.03~2021.03, National Cancer Center, Bioinformatics analysis Team, Chief

 

주요연구분야

Bioinformatics, Cancer genomics, computational biology

 

대표 연구(학술) 활동

• Refining Classification of Cholangiocarcinoma Subtypes via Proteogenomic Integration Reveals New Therapeutic Prospects. Gastroenterology. 2023 Jun;164(7):1293-1309. doi: 10.1053/j.gastro.2023.02.045. Epub 2023 Mar 9. Erratum in: Gastroenterology. 2023 Nov;165(5):1313. PMID: 36898552.
• Histamine Signaling Is Essential for Tissue Macrophage Differentiation and Suppression of Bacterial Overgrowth in the Stomach. Cell Mol Gastroenterol Hepatol. 2023;15(1):213-236. doi: 10.1016/j.jcmgh.2022.09.008. Epub 2022 Sep 24. PMID: 36167263; PMCID: PMC9672892.
• Single-cell analysis of gastric pre-cancerous and cancer lesions reveals cell lineage diversity and intratumoral heterogeneity. NPJ Precis Oncol. 2022 Jan 27;6(1):9. doi: 10.1038/s41698-022-00251-1. PMID: 35087207.

 

주요 강의 과목

생물통계학, 생물정보학, 일반데이터사이언스

학력

• 1989년도: 한양대학교 생화학과 학사
• 1995년도: 호주 모나쉬대학교 박사

 

경력

• 1996-1997.08 Postdoctoral Fellow, Stanford University, USA
• 1997.09-현재 교수, 한양대학교 의약생명과학과
• 2000.05-2014.12 대표이사, (주)지노첵
• 2007.03-2017.12 BioChip Journal(SCIE 저널)Editor-in-Chief
• 2009.01-2010.12 Molecular & Cellular Toxicology(SCIE 저널) Editor-in-Chief
• 2011.01-2012.12 대한독성유전단백체학회 회장
• 2014.12-2020.08 바이오코아(주) 대표이사
• 2019.01-2019.12 한국바이오칩학회회장

 

주요연구분야

• 1) Research on environmental diseases using multi-omics technology
• 2) Development of molecular diagnostic kits

 

대표 연구(학술) 활동

• 1) Effects of Low-level Toluene Exposure on the Nervous System of Mothers and Infants. International Journal of Molecular Sciences 2024 25(11):6215.
• 2) Stratum Corneum Lipid and Cytokine Biomarkers at age 2 Months Predict the Future Onset of Atopic Dermatitis. Journal of Allergy and Clinical Immunology 2023 151(5):1307-1316.
• 3) Simultaneous detection of SARS-CoV-2 and identification of spike D614G mutation using point-of-care real-time polymerase chain reaction. Journal of Virological Methods 2022 304:114513.
• 4) Prenatal Exposure to Heavy Metals Affects Gestational Age by Altering DNA Methylation Patterns. Nanomaterials 2021 11(11):2871.
• 5) Rapid Subtyping and Pathotyping of Avian Influenza Virus using Chip-based RT-PCR. BioChip Journal 2019 13(4):333–340.

 

주요 강의 과목

• 1) 일반생물학
• 2) 유전학

학력

• B.S. in Molecular Biology 2011 – 2015
  Dankook university
• Ph.D. in Biomedical Sciences 2015 – 2021
  Yonsei university

 

경력

• Postdoctoral Research Associate 2021 – 2023
• Departmentof Biomedical Science, Yonsei University
• Postdoctoral Research Fellow 2023 – 2025
• Departmentof Section of Surgical Sciences, Vanderbilt University Medical Center

 

주요연구분야

• 1) Epithelial cell-based pathological and physiological research.
• 2) Defining the molecular mechanisms of stepwise cancer progression in stomach.
• 3) Studying on interaction between microbes and epithelial cells.
• 4) Basic and Translational research using pre-clinical model and organoids.

 

대표 연구(학술) 활동

• 참조 링크: https://scholar.google.com/citations?user=IujSQZgAAAAJ&hl=ko&oi=ao
• 1. Jeong H*, Lee B*, Cho SY, Lee Y, Kim J, Hur S, Cho K, Kim KH, Kim SH, Nam KT. Microbiota-derived short-chain fatty acids determine stem cell characteristics of gastric chief cells. Developmental Cell. 2025; S1534-5807(24)00672-5.
• 2. Yang M*, Kim Y*, Youn S-Y*, Jeong H*, Shirbhate ME, Uhm C, Kim G, Nam KT, Cha S-S, Kim KM, Yoon J. Conversion of albumin into a BODIPY-like photosensitizer by a flick reaction, tumor accumulation and photodynamic therapy. Biomaterials. 2025; 313:122792.
• 3. Jeong H*, Lee N, Uhm C, Cho K, Oh H, Oh Y, Zhang K, Kim HL, Goldenring JR, Lim KM, Park CO, Nam KT. RAB25 coordinates filaggrin-containing keratohyalin granule maturation and affects atopic dermatitis severity. Allergy. 2023; 78(4):1007-1019.
• 1. Jeong H*, Lee B*, Kim KH, Cho SY, Cho Y, Park J, Lee Y, Oh Y, Hwang BR, Jang AR, Park JH, Park JH, Jeong SH, Lee D, Lee YC, Lim KM, Goldenring JR, Nam KT. WFDC2 promotes spasmolytic polypeptide-expressing metaplasia through the upregulation of IL33 in response to injury. Gastroenterology. 2021; 161(3):953-967.
• 1. Jeong H*, Lim KM*, Kim KH, Cho Y, Lee B, Knowles BC, Roland JT, Zwerner JP, Goldenring JR, Nam KT. Loss of Rab25 promotes the development of skin squamous cell carcinoma through the dysregulation of integrin trafficking. J Pathol. 2019; 249(2):227-40.

 

주요 강의 과목

• 1) 일반생물학
• 2) 분자병리학